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Why do we need to test the hardness of newly developed tablets?

2017-11-16
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Why do we need to test the hardness of newly developed tablets?

The hardness of a tablet generally refers to its compressive strength, that is, the radial crushing force of the tablet. Hardness is not a simple physical concept, but a comprehensive index of mechanical properties such as material elasticity, plasticity, strength and toughness.



2.In the 2010 edition of the Chinese Pharmacopoeia, tablets account for more than 40% of all preparations. In the Pharmacopoeia, relevant national departments fully clarify the regulations that tablets should comply with during production and storage, and establish the weight difference and disintegration time limit of tablets. , dissolution or release, content uniformity and other inspection methods. It plays a big role in ensuring the quality of tablets.




3. In addition to ensuring the above indicators, tablets should also have appropriate hardness to facilitate complete molding, meet the requirements for tablet appearance and not be easily brittle. 

4. The hardness of tablets involves the appearance quality and intrinsic quality of tablets. Excessive hardness will affect the disintegration and release of tablets to a certain extent. Therefore, it must be controlled during the production process of tablets. With the modernization of tablet research and production in our country. The testing of tablet hardness has been listed as one of the very important testing items in the tableting process.




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